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在患有代谢综合征的患者减肥手术后的短期心血管事件
Maryna Chumakova-Orin1, Jennifer L Ingram2, Loretta G Que2
1Department of Surgery, Dignity Health, Santa Maria, California.
概括
患有代谢综合征 (MetS) 的患者在减肥手术后面临更高的重大心血管不良事件 (MACE) 风险. 本研究量化了这些风险,强调了需要更好地进行手术前管理的必要性.
科学领域:
- 心血管外科心血管外科
- 代谢障碍 代谢障碍 代谢障碍
- 减肥医学 减肥医学
背景情况:
- 代谢综合征 (MetS) 患者患有心血管疾病和腹腔外科手术后不良事件的风险增加.
- 在接受减肥手术的MetS患者中,主要心血管不良事件 (MACE) 的短期发病率尚不清楚.
研究的目的:
- 在接受低体重手术的MetsS患者中描述短期MACE的发生率.
- 为了比较MetS和没有MetS的患者之间的结果,考虑高脂血症 (HLD).
主要方法:
- 从美国和加拿大认可的中心 (2015-2018) 分析了760,076次初级减肥手术.
- 定义 MetS 队列为糖尿病和高血压患者.
- 评估了30天的MACE (心肌梗塞,中风,全因死亡率) 使用逻辑回归,包括MetS和HLD相互作用.
主要成果:
- 在包括的577,882名患者中,有19.2%患有MetS.
- 在MetS患者中,MACE发病率显著更高 (0.3%与1.1%相比;P<.001).
- 未经调整的分析显示,MetS增加了MACE几率 (OR2.87),与HLD没有的非MetS相比,MetS与HLD没有的非MetS有显著的关联.
结论:
- 代谢综合征与减肥手术后心脏事件频率增加有关.
- 需要进一步的研究来确定优化MetS组件是否可以减轻这些患者的心血管风险.
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