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相关概念视频

Menopause01:28

Menopause

200
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
200
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

435
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
435
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

565
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
565
Menses Phase01:18

Menses Phase

306
The uterine cycle begins with the menstrual phase, which is considered day one of the cycle and typically lasts about five days. This phase is characterized by the degeneration and shedding of the stratum functionalis, the functional layer of the endometrium.
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
306
The Menstrual Cycle01:19

The Menstrual Cycle

896
The menstrual cycle is a recurrent sequence of changes in the uterine endometrium, specifically its functional layer, the stratum functionalis. This cycle prepares the uterus for potential pregnancy. This cycle typically spans 21–35 days, averaging 28 days, and aligns with the ovarian cycle, regulated by fluctuating levels of ovarian hormones, primarily estrogen and progesterone.
The menstrual phase occurs from days 1 to 5 and involves the shedding of the stratum functionalis, as a...
896
Birth Control Methods01:22

Birth Control Methods

327
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
327

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相关实验视频

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An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
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对更年期的非雌激素基础和补充疗法.

Bassel H Al Wattar1, Vikram Talaulikar2

  • 1Beginnings Assisted Conception Unit, Epsom and St Helier University Hospitals, London, UK; Comprehensive Clinical Trials Unit, Institute for Clinical Trials and Methodology, University College London, London, UK.

Best practice & research. Clinical endocrinology & metabolism
|September 2, 2023
PubMed
概括

有效地管理更年期症状需要采用整体方法. 包括药物和疗法在内的非荷尔蒙选择为经历衰弱的更年期症状的女性提供了替代方案.

关键词:
这是一个互补的互补.更年期 绝经 绝经非荷尔蒙疗法的治疗.补充剂 补充剂 补充剂维生素 维生素 维生素 是一种

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Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
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A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
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A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
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科学领域:

  • 生殖医学 生殖医学
  • 妇女健康 妇女健康
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 更年期对妇女的生活质量产生重大影响,许多人寻求缓解衰弱症状.
  • 个人的更年期经历各不相同,需要个性化管理策略.
  • 结合生活方式,荷尔蒙和非荷尔蒙干预的整体方法对于最佳健康至关重要.

研究的目的:

  • 审查管理更年期症状的非荷尔蒙干预措施.
  • 讨论药理和非药理选择的疗效和副作用.
  • 突出新兴的治疗方法,如神经素受体3抗剂.

主要方法:

  • 对药理学非激素药物 (SSRI,SSRI/SNRIs, gabapentin,pregabalin) 的文献综述.
  • 对非激素药物克隆丁和认知行为疗法 (CBT) 的评估.
  • 对草药,替代疗法和神经素受体3抗剂的证据评估.

主要成果:

  • SSRI,SSRI/SNRIs,加巴丁和普雷加巴林在血管运动和其他更年期症状方面表现出有效性,常见副作用.
  • 克洛尼丁是英国许可的血管运动症状,但有显著的副作用.
  • 建议对焦虑,睡眠问题和血管运动症状进行CBT;对替代疗法的证据较弱.

结论:

  • 非激素药理选择和CBT对于管理更年期症状是有价值的.
  • 新兴的治疗方法,如神经素受体3抗剂,对热有很大的希望.
  • 需要进一步的研究来确定替代疗法的疗效和安全性.