动态处理方案使用贝叶斯增量回归树对受审查的结果
Xiao Li1, Brent R Logan1, S M Ferdous Hossain2
1Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, USA.
Lifetime data analysis
|September 2, 2023
概括
本研究引入了使用贝叶斯增量回归树 (BART) 的贝叶斯方法,以优化针对审查结果的动态治疗方案 (DTR). 这种方法为个性化癌症治疗策略的Q学习等频率主义方法提供了灵活的替代方案.
科学领域:
- 生物统计学 生物统计学
- 机器学习 机器学习
- 医疗信息学 医疗信息学
背景情况:
- 个性化医疗需要定制的治疗计划,特别是对于癌症等进展性疾病.
- 动态治疗方案 (DTRs) 正式化了疾病进展中的顺序决策.
- 现有的DTR优化方法,如Q学习,主要是频率主义的.
研究的目的:
- 适应贝叶斯的机器学习框架,以优化DTR与受审查的结果.
- 为了比较建议的贝叶斯方法与频率主义的Q学习方法.
- 开发一个实用的R工具来实施拟议的方法.
主要方法:
- 在加速失效时间 (AFT) 建模框架内利用贝叶斯增量回归树 (BART).
- 将方法应用于模拟数据和真实世界数据集.
- 开发了一个R封装功能,利用标准的BART生存模型.
主要成果:
- 建议的贝叶斯DTR优化方法在审查结果方面表现出有效性.
- 模拟和真实数据分析显示了与Q学习相比的可比或更好的性能.
- R包装功能提供了一个用户友好的界面来应用该方法.
结论:
- 使用BART的贝叶斯DTR优化为被审查的数据提供了强大而灵活的方法.
- 这一框架在复杂的医疗场景中促进了个性化治疗策略.
- 开发的R工具提高了研究人员和临床医生的可访问性.
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