入院患者接受罗塞米德接受急性损伤:风险和预测工具
Chen Guan1, Chenyu Li2, Lingyu Xu1
1Department of Nephrology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, China.
European journal of medical research
|September 2, 2023
概括
罗塞米德的使用增加了在医院获得的急性损伤 (HA-AKI) 的风险,特别是在高剂量或与某些药物结合使用时. 一个新的名图有助于预测furosemide患者的HA-AKI风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床药理学 临床药理学
- 医院 医院 医疗 医疗 医疗 医疗
背景情况:
- 富罗塞米德是一种常见的利尿剂,用于心力衰竭和水.
- 它在引起急性损伤 (AKI) 中的作用受到争论.
- 住院获得的AKI (HA-AKI) 是住院患者的一个重大问题.
研究的目的:
- 为了调查接受罗西米德的患者中HA-AKI的发生率.
- 为了确定与罗胺诱导的HA-AKI相关的风险因素.
- 开发一个预测HA-AKI在furosemide用户的模型.
主要方法:
- 一项对22374名住院患者 (2012年6月至2017年12月) 的回顾性队列研究.
- 倾向性得分匹配被用来比较furosemide和非furosemide组.
- 开发并验证了一种预后性脑图,以预测HA-AKI风险.
主要成果:
- 富罗塞米德的单日总剂量是AKI最重要的风险因素.
- 同时使用抗生素,β抑制剂和ACEI/ARB增加了AKI风险.
- 一个预测性名图显示,预测HA-AKI的准确率为77.40%.
结论:
- 关于罗西米德的临床决定应考虑剂量,并发药物和患者的功能.
- 一个实用的预后模型可以帮助临床医生管理HA-AKI风险.
- 这种模型有助于为furosemide用户提供明智的患者护理和治疗策略.
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