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在多种组织中评估儿科表观遗传钟

Fang Fang¹, Linran Zhou², Wei Perng³

¹GenOmics and Translational Research Center, RTI International, Research Triangle Park, 3040 East Cornwallis Road, Durham, NC, 27709-2194, USA. ffang@rti.org.

Clinical epigenetics

|September 2, 2023

概括

儿科表观遗传钟准确地确定了生物年龄. 不同的时钟在各个组织中表现不同,对儿童的血液,胎盘和口腔细胞提出了具体建议.

科学领域:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
基因组学就是基因组学.
生物技术是生物技术.

背景情况:

表观遗传钟正在成为估计生物年龄的强大工具.
在儿科患者群体中,对生物年龄的准确评估至关重要.

研究的目的:

评估儿科表观遗传钟用于确定妊娠和时间年龄的准确性.
为了比较不同儿科组织类型中各种表观遗传钟的性能.

主要方法:

使用三种微阵列分析来自七种组织类型的DNA甲基化数据.
对已建立的儿科表观遗传钟进行比较评估.

主要成果:

骑士和博林钟表在血液细胞中表现出类似的准确性.
李时钟在胎盘样本中表现出卓越的性能.
儿科-口腔-表观遗传时钟对于口腔样本是最佳的.
霍瓦斯时钟推用于儿科血细胞.
新时代时钟准确地预测了婴儿口腔细胞的月经后年龄.

结论:

这项研究为在儿科研究中选择适当的表观遗传钟提供了必要的指导.
这些发现有助于使用表观遗传数据对儿童的生物年龄进行更精确的评估.

关键词:

通过DNA甲基化.儿童早期时间表年龄年代表年龄基因表观时钟是什么?怀孕年龄怀孕年龄

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