移动时区在一个闪光灯与光疗法在睡眠期间的闪光
Renske Lok1, Marisol Duran2, Jamie M Zeitzer3,4
1Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, USA.
Scientific reports
|September 2, 2023
概括
闪光疗法,在睡眠期间使用短暂的光脉冲,有效地延迟了人类的昼夜钟. 这种新的方法显示了显著的阶段变化,睡眠中断最小,为轮班工人和旅行者提供了潜力.
科学领域:
- 时间生物学 时间生物学
- 睡眠科学 睡眠科学
- 光疗法是一种照明疗法.
背景情况:
- 持续暴露于光线是改变人类昼夜时钟定时的已知方法.
- 研究睡眠期间间歇性光照的研究,为昼夜节律操纵提供了一种新的方法.
研究的目的:
- 评估睡眠期间间歇性闪光灯在改变昼夜时间的有效性.
- 评估这种"闪光疗法"对睡眠架构和光谱功率的影响.
主要方法:
- 健康的参与者 (n=10) 接受了两个实验室会议,包括安慰剂和60分钟的闪光疗法干预,在习惯性睡眠开始时进行干预.
- 闪光疗法包括每15秒发射2毫秒的宽频光脉冲.
- 使用唾液暗光黑激素发作 (DLMO) 测量循环节相位变化;通过多睡眠学监测睡眠.
主要成果:
- 与安慰剂 (12 ± 20 分钟) 相比,闪光疗法诱导了DLMO (1.13 ± 1.27 小时) 的显著延迟.
- 两名参与者表现出异常大的6.4小时和3.1小时的相位延迟.
- 没有观察到睡眠结构的显著变化,尽管注意到一些睡眠不稳定性.
结论:
- 在睡眠期间进行一小时的闪光疗法可以有效地延迟昼夜时钟,并可能发生长达6小时的轮班.
- 这种方法似乎对睡眠质量的影响最小.
- 闪光疗法为经历昼夜干扰的个体,如轮班工人和喷气式飞机旅行者,提供了一个有希望的,实用的生理时钟调整策略.
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