萨卢布里纳尔可以缓解子关节骨关节炎模型的软骨退化
Ting Xu1, Jing Shuai2, Zhiyuan Gu3
1Department of Stomatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Oral diseases
|September 3, 2023
概括
内注射可以通过减少软骨退化和内质网膜 (ER) 应激减轻关节骨关节炎 (TMJOA). 这项研究表明Salubrinal作为TMJOA的潜在治疗方法.
科学领域:
- 生物医学研究的研究.
- 整形外科 整形外科 整形外科
- 药理学 药理学是指药理学的学科.
背景情况:
- 关节骨关节炎 (TMJOA) 是一种退行性关节疾病.
- 前盘位移 (ADD) 是TMJOA的一个常见原因.
- 细胞内膜网膜 (ER) 的压力在TMJOA的发病过程中起作用.
研究的目的:
- 在子模型中研究Salubrinal对TMJOA的治疗作用.
- 阐明Salubrinal对软骨退化和ER压力的作用背后的机制.
主要方法:
- 在子中手术诱导ADD.
- 在关节内注射Salubrinal.
- 组织学分析,TUNEL染色,免疫组织化学,qPCR和西欧斑点.
主要成果:
- 萨卢布林治疗部分逆转了状软骨的恶化.
- 它减少了状细胞的亡,并增加了细胞外基因组件 (原II,Aggrecan).
- 沙鲁布林降低了催化因子 (MMP13,ADAMTS5,VEGF,TNF-α,IL-1β),抑制了ER压力标志物 (GRP78,CHOP,ATF4,Caspase-12),并抑制了NF-κB的激活.
结论:
- 在ADD诱导的TMJOA子模型中,Salubrinal有效地减轻了软骨退化.
- 关节内Salubrinal注射显示出作为TMJOA治疗策略的潜力.
- 抑制ER压力和NF-κB激活是Salubrinal有益作用的关键机制.
相关概念视频
01:27Fractures: Bone Repair
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...