在患有孤立REM睡眠行为障碍的患者中,先前暴露于脑震荡
Mónica Roig-Uribe1, Mònica Serradell1, Amaia Muñoz-Lopetegi1
1Sleep Disorders Center, Neurology Service, Hospital Clínic Barcelona, Universitat de Barcelona, IDIBAPS, CIBERNED: CB06/05/0018-ISCIII, Barcelona, Spain.
Sleep medicine
|September 3, 2023
概括
脑震荡史在患有孤立REM睡眠行为障碍 (IRBD) 的人中更为常见. 早期的头部受伤可能会导致后期的IRBD发展,这强调了预防创伤性脑损伤的重要性.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 睡眠医学 睡眠医学
背景情况:
- 创伤性脑损伤 (TBI) 与晚期发作的神经退行性疾病有关,包括同核蛋白病变.
- 孤立REM睡眠行为障碍 (IRBD) 是同核蛋白病变的早期指标.
研究的目的:
- 调查IRBD患者中脑震荡发作的发生率.
- 在IRBD的背景下,研究脑震荡的特征和临床意义.
主要方法:
- 采访了经过多睡眠检查确认的IRBD患者和对照组.
- 用BRAIN-Q问卷来评估先前的脑震荡暴露.
- 评估了患者脑震荡史,时间和临床结果.
主要成果:
- 与对照组 (10.1%) 相比,IRBD患者中脑震荡史的发生频率明显高 (21.1%).
- 脑震荡发生在IRBD患者的平均年龄为24.7岁,IRBD诊断发生43年后.
- 两组之间在脑震荡严重程度或即时医疗结果方面没有发现差异.
- 在IRBD诊断后,在有或没有脑震荡病史的患者中,发展明显的协核蛋白病变的风险类似.
结论:
- 在IRBD患者中,脑震荡史是普遍存在的.
- 早期脑震荡可能会在易受影响的个体中启动缓慢的神经退行级联,几十年后导致IRBD.
- 这些发现强调了对头部伤害预防策略的迫切需要,特别是在生命早期.
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