在logopenic变体中的术语失语症初级渐进性失语症
Mario F Mendez1, Alexander Sheppard2, Diana Chavez3
1Department of Neurology, David Geffen School of Medicine, University of California Los Angeles (UCLA), USA; Department of Psychiatry and Behavioral Sciences, David Geffen School of Medicine, University of California Los Angeles (UCLA), USA; Neurology Service, Neurobehavior Unit, V.A. Greater Los Angeles Healthcare System, USA.
几乎10%的罗格变异原发性渐进性失言症 (lvPPA) 患者表现出术语失言症,其特点是无法理解的言语. 这种表现,通常与阿尔茨海默病 (AD) 相关,涉及双边大脑低代谢和语言理解障碍.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 语言学的语言学.
背景情况:
- 逻辑变异性初级渐进性失语症 (lvPPA) 是一种渐进性语言障碍,经常是阿尔茨海默氏症 (AD) 的早期形式.
- 患有lvPPA的患者在词汇检索和语言表达方面遇到困难.
- 误诊是常见的,当lvPPA呈现为术语失语时,标志着难以理解的语言.
研究的目的:
- 为了识别和表征 lvPPA 的患者,他们出现了术语失语.
- 为了区分 lvPPA 中的术语失语与其他失语表现.
主要方法:
- 在23年内对符合lvPPA标准的患者进行了回顾性审查.
- pozitron发射断层扫描 (PET) 脑部扫描被用于评估.
- 在lvPPA队列中,专门识别和分析了术语失语患者.
主要成果:
- 在95名 (9.47%) lvPPA患者中,有9人出现了术语失语.
- 术语迷失症患者对缺陷的意识减少,精神状况较差,理解难度更大.
- 双边的temporo-parietal低代谢在术语失调患者中更为普遍.
- 在44.4%的术语失语患者中观察到双语或多语种,而在其他患者中则为14%.
结论:
- 大约十分之一的lvPPA患者表现出严重难以理解的语言 (术语失语).
- 这种表现与影响语言和意识的双边temporo-parietal疾病有关.
- 在lvPPA中,术语失语需要与其他失语症和精神疾病区分开来.
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