环境颗粒物,母亲的甲状腺功能和出生体重:调解分析.
Yuting Gong1, Yueshu Zhao2, Xiaoan Zhang2
1Department of Medical Genetics, Henan Provincial People's Hospital; People's Hospital of Zhengzhou University, Zhengzhou, China; School of Public Health, Zhengzhou University, Zhengzhou, China.
Ecotoxicology and environmental safety
|September 3, 2023
概括
母亲接触细颗粒物 (PM) 与降低出生体重 (BW) 有关. 甲状腺激素水平调解了这种效应,这表明PM诱导的胎儿生长减少的途径.
科学领域:
- 环境健康 环境健康
- 生殖健康 生殖健康
- 内分泌学 在内分泌学.
背景情况:
- 出生体重 (BW) 是胎儿发育的一个关键指标.
- 之前对环境颗粒物 (PM) 和BW的研究已经产生了不一致的结果.
- 在这种关联中,母亲甲状腺功能的作用仍然不清楚.
研究的目的:
- 调查母亲暴露于PM2.5和PM10与出生体重之间的关联.
- 为了检查母亲甲状腺激素水平对这种关系的影响.
- 探索母亲甲状腺激素在PM-BW协会中的调解作用.
主要方法:
- 在中国河南招募了1711名孕妇,跟踪她们直到分娩.
- 使用时空模型评估每日PM2.5和PM10度.
- 用线性回归和因果调解分析测量了母亲甲状腺激素水平,并分析了与BW的关联.
主要成果:
- 增加的PM2.5和PM10暴露与降低出生体重有关.
- 孕产妇的FT4水平与出生体重呈反向相关性.
- 母亲的FT4水平与PM暴露呈正相关性,介于PM-BW关系的5.55%至15.86%.
结论:
- 母亲接触颗粒物可能会降低新生儿的出生体重.
- 这种减少可能是由于母亲甲状腺激素度的改变而引起的.
- 研究结果强调甲状腺功能是将空气污染与胎儿生长联系起来的关键途径.
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