心率和自主生物标志物区分了性与功能性或离散性发作
Justin M Ryan1, Kyle T Wagner1, Sushma Yerram2
1Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY 13210, United States.
Seizure
|September 3, 2023
概括
心率变化 (HRV) 的测量可以区分发作 (ES) 和功能性或离散性发作 (FDS). 这种自主功能分析为区分这些发作类型,特别是发作事件提供了新的诊断工具.
科学领域:
- 神经科学是一个神经科学.
- 心脏病学 心脏病学
- 自主神经系统研究 自主神经系统研究
背景情况:
- 患有不受控制的发作的人中有很大一部分经历了类似发作 (ES) 的事件,但缺乏EEG相关物,称为功能性或离散性发作 (FDS).
- 目前用于区分ES和FDS的诊断方法,如EEG监测,具有包括可访问性和不确定的结果在内的局限性.
研究的目的:
- 开发和评估一种替代诊断工具,以区分发作 (ES) 和功能性或离散性发作 (FDS).
- 评估基于心电图 (ECG) 的心率变化 (HRV) 测量自主功能的时间演变,以区分ES与FDS.
主要方法:
- 一项前性研究,涉及18-65岁的患者,他们被录入监测单元,但不包括那些治疗或影响自主功能的并发症患者.
- 记录了习惯性ES或FDS事件,在心率 (HR) 和HRV分析期间进行了心跳周期 (心跳前后150分钟).
- 统计分析确定自主测量是否可以区分ES和FDS,按和非事件分层.
主要成果:
- 在ES和FDS之间,HR和自主功能的时间变化显著不同.
- 发作后的HR,总自主功能 (SDNN,总功率),阴道功能 (RMSSD,HF) 和巴罗反射功能 (LF) 区分了性ES和性FDS.
- 结合HR变化和点击后HR的模型显示,对于性ES与FDS,诊断准确度高 (92%的灵敏度,94%的特异性,ROC为0.99).
结论:
- 心率和HRV的测量有效地区分了性发作与性功能性或离散性发作.
- 非性事件的诊断准确性较低,表明需要进一步研究.
- 这些发现为利用HRV作为不同人群和医院外环境中的非侵入性诊断工具提供了一个框架.
更多相关视频
10:22Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
Published on: December 6, 2016
20.4K
08:28Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
Published on: April 5, 2011
17.8K
相关概念视频
01:13Seizures: Classification
408
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
408
01:24Arteries of the Lower Limbs
212
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
212