帕金森病的进展:一个不变的共同核心子网络的表达越来越多
Phoebe G Spetsieris1, David Eidelberg2
1Center for Neurosciences, The Feinstein Institutes for Medical Research, Manhasset, NY 11030, United States.
NeuroImage. Clinical
|September 3, 2023
概括
稀有反向共变率估计 (SICE) 与主要成分分析 (PCA) 确定了一个核心帕金森病 (PD) 脑网络. 该网络的连接性随着疾病持续时间的增加而增加,为疾病修饰提供了潜在的目标.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 计算生物学 计算生物学
背景情况:
- 像帕金森病 (PD) 这样的神经退行性疾病给研究带来了重大挑战.
- 定子发射断层扫描 (PET) 和主要成分分析 (PCA) 和稀疏逆共变率估计 (SICE) 等还原技术在研究PD方面表现有前途.
- 之前的研究表明PCA在优化SICE用于PD代谢扫描中的实用性.
研究的目的:
- 通过疾病特定的子网络分区来增强SICE的潜力,以确定PD中的关键区域枢纽及其连接.
- 追踪这些枢纽和连接在PD患者中与疾病持续时间增加的关联.
- 了解PD相关大脑网络中的功能代谢连接的渐进变化.
主要方法:
- 使用稀疏反向协差估计 (SICE),增强了主要组件分析 (PCA) 衍生的疾病特定子网络分区.
- 将该方法应用于帕金森病 (PD) 患者的代谢PET扫描,症状持续时间不同.
- 确定了核心大脑区域及其功能代谢连接模式.
主要成果:
- 确定了一个核心大脑网络,包括条纹体,pons,小脑虫和表皮层.
- 这个核心子网络展示了强大的,不变的疾病特征,独立于表型.
- 该子网络的平均表达水平在初级队列中随着疾病持续时间 (1-21年) 稳步增加,并在单独的队列中得到验证 (长达32年).
结论:
- 已识别的核心网络代表了帕金森病中疾病修饰疗法的潜在目标.
- 这个网络中的连接变化与疾病进展相关.
- 与外部区域的联系可能与症状治疗策略有关.
相关概念视频
01:15Parkinson's Disease: Overview
593
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
593
01:37Neural Regulation
39.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.5K
01:24Parkinson's Disease: Treatment
295
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
295
01:26Alzheimer's Disease: Overview
517
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
517
01:22Alzheimer's Disease: Treatment
212
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
212
02:07Tumor Progression
6.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K