抗微生物治疗的不精确性:基于结果的模型来关闭数据到行动的循环
Alex Howard1, Nada Reza2, Stephen Aston2
1Department of Antimicrobial Pharmacodynamics and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK; Department of Infection and Immunity, Liverpool Clinical Laboratories, Liverpool University Hospitals NHS Foundation Trust, Royal Liverpool Site, Liverpool, UK.
The Lancet. Infectious diseases
|September 3, 2023
概括
抗微生物药物耐药性是一个主要威胁. 这项研究提出了"不准确性",这是衡量不适当使用抗微生物药物的新指标,指导更好的管理和可持续实践.
科学领域:
- 公共卫生 公共卫生
- 卫生政策 卫生政策
- 传染病管理 传染病管理
背景情况:
- 抗菌素耐药性 (AMR) 对医疗保健系统和社会构成重大全球威胁.
- 不适当的抗微生物治疗是AMR的一个关键驱动因素.
- 目前的抗菌药物管理框架缺乏基于结果的措施来量化与治疗相关的损害.
研究的目的:
- 引入"不精确性",一种新的,基于数学的,基于结果的指标,用于评估抗菌药物治疗的适当性.
- 提出一个框架,利用这个指标来加强抗菌药物管理干预措施.
- 引导政策制定者和医疗保健领导人制定更有效的抗AMR策略.
主要方法:
- 基于数学原理和结果测量的新指标"不精确度"的开发.
- 概述一个政策和医疗保健领导框架,以实施不准确度指标.
- 利用学习抗微生物系统,公众参与,实施科学,人工智能和监管改革.
主要成果:
- 拟议的"不精确"指标为抗微生物治疗的适当性提供了有形的,基于结果的衡量标准.
- 该框架有助于制定更有效的抗微生物管理干预措施.
- 实施得到了AI,公众参与和更新的法规的支持.
结论:
- 采用"不精确"指标可以导致更可持续的抗微生物药物开发,监管和处方模式.
- 人工智能增强的抗微生物治疗不准确性的测量可以为未来的患者途径和药物开发提供信息.
- 解决实际,伦理和监管方面的考虑对于成功实施至关重要.
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