比较ceftolozane/tazobactam与piperacillin/tazobactam用于尿路感染的初始实证治疗:一个回顾性比较研究
Tomomi Nakagawa1, Kazuyoshi Shigehara1, Rei Shinzawa1
1Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
概括
塞夫托洛赞/塔扎巴克坦 (CTLZ/TAZ) 是比比帕西林/塔扎巴克坦 (PIPC/TAZ) 的可行的替代品,用于治疗复杂的尿路感染 (UTI). 两种抗生素的短期和长期临床疗效和微生物学结果都相似.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 复杂的尿路感染需要有效的抗生素治疗.
- 塞夫托洛赞/塔扎巴克坦 (CTLZ/TAZ) 和皮佩拉西林/塔扎巴克坦 (PIPC/TAZ) 是常用于治疗尿路感染的抗生素.
研究的目的:
- 为了比较CTLZ/TAZ与PIPC/TAZ在治疗复杂囊炎或急性肺炎的临床和微生物疗效.
- 评估短期和长期的临床结果,以及微生物根除率.
主要方法:
- 这是一项回顾性研究,比较了52名接受CTLZ/TAZ治疗的患者和47名接受PIPC/TAZ治疗的患者.
- 收集了关于患者人口统计,尿路感染类型,致病微生物和治疗结果的数据.
主要成果:
- 两组之间患者背景没有显著差异.
- 短期临床疗效率为CTLZ/TAZ的80.8%和PIPC/TAZ的87.2%.
- 长期不复发率为CTLZ/TAZ的95.1%和PIPC/TAZ的89.7%.
- 对CTLZ/TAZ的微生物学疗效率为72.7%,对于PIPC/TAZ的疗效率为86.0%.
- 两组之间在短期或长期临床疗效方面没有发现显著差异.
结论:
- 在治疗复杂的尿路感染方面,CTLZ/TAZ证明与PIPC/TAZ无劣.
- CTLZ/TAZ是一种适合于经验性治疗尿路感染的替代抗生素.
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