环境空气污染与甲状腺激素水平之间的关联:系统性审查和元分析
Jintao Liu1, Kefu Zhao2, Tingting Qian1
1Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, China.
The Science of the total environment
|September 3, 2023
概括
空气污染,包括细颗粒物 (PM2.5) 和二氧化 (NO2),与较低的甲状腺激素水平有关. 怀孕早期的暴露可能特别影响甲状腺功能,突出显示了公共卫生方面的担忧.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 越来越多的证据表明,环境空气污染会影响甲状腺激素 (THs),但这些发现是不一致的.
- 进行了系统审查和元分析,以巩固目前关于这种关联的证据.
研究的目的:
- 系统地审查和元分析暴露于环境空气污染物和甲状腺激素水平之间的关联.
- 为了确定与甲状腺功能改变相关的特定污染物和暴露条件.
主要方法:
- 搜索了四个数据库对颗粒物 (PM10,PM2.5) 和气态污染物 (SO2,NO2,O3,CO) 的研究及其与THs的关联.
- 采用随机效应模型汇集数据,并根据地区,研究设计,样本大小,污染物度和暴露窗口进行分组分析.
主要成果:
- 包括14项研究,共357226名参与者. 在PM2.5,PM10,NO2,SO2和CO暴露和自由甲状腺素 (FT4) 水平之间发现了显著的负相关性.
- PM2.5,NO2和CO与FT4/FT3水平有负相关性. 暴露于PM2.5与低甲状腺素和高甲状腺刺激激素 (TSH) 有关.
- 亚组分析显示,在中国人口,污染较高的地区和更大的样本大小中,相关性更强. 产前的PM2.5暴露与孕妇的FT4降低有关.
结论:
- 空气污染暴露明显与甲状腺激素水平的改变有关.
- 公共卫生战略应侧重于管理受污染地区,识别颗粒物来源,保护孕妇免受有害暴露.
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