开发基于奇托桑的β-胡卜素粘粘合剂配方,用于治疗皮肤癌
Farah Azhar1, Humaira Naureen2, Gul Shahnaz3
1Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan; Stanford Advanced Drug Delivery and Regenerative Biomaterials Lab, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
International journal of biological macromolecules
|September 3, 2023
概括
硫化基-石英酸纳米粒有效地为皮肤癌治疗提供β-胡卜素. 这种新的配方增强了药物透,并在临床前研究中显示出抗癌性质.
科学领域:
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 粘膜透纳米配方可以改善药物输送,以改善溶解性较差的化合物.
- 一种植物化学物质β-胡卜素具有抗癌特性,但需要增强的输送系统.
研究的目的:
- 设计和表征带有β-胡卜素的化基 (TCS) - 石灰酸 (LA) 纳米细胞.
- 评估开发的用于皮肤癌治疗的纳米配方的粘膜粘合,粘膜透和抗癌潜力.
主要方法:
- 使用FTIR,XRD,DSC,DLS和TEM合成和描述TCS-LA纳米细胞.
- 确定β-胡卜素捕获和加载效率.
- 在小鼠体内粘粘结,ex vivo粘膜透,以及体内抗癌研究.
主要成果:
- TCS-LA纳米细胞表现出有利的物理化学特性 (大小<300 nm,表面电荷+27.0 mV).
- 为β-胡卜素实现了高捕获 (64%) 和加载 (58%) 的效率.
- 该配方在体内证明了持续的药物释放,增强的粘膜粘附,以及皮肤癌生长的显著延迟.
结论:
- TCS-LA纳米细胞代表了一种新的,稳定的,有效的粘膜配方,用于提供β-胡卜素.
- 这种纳米配方对皮肤癌的潜在治疗有希望.
- 该研究强调了将纳米技术与天然化合物相结合的潜力,以改善治疗结果.
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