间歇性多药IV疗法对耐火性mycobacterium的结果 肺部疾病
Yunjoo Im1, Su-Young Kim1, Dae Hun Kim1
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Chest
|September 3, 2023
概括
间歇性多药IV疗法 (IMIT) 为耐火性Mycobacterium abscessus肺病 (MAB-PD) 提供了一种有益的息方法. 这种治疗可以缓解症状,并减缓MAB-PD患者的疾病进展.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 耐火性Mycobacterium的肺病 (MAB-PD) 缺乏确定的治疗方案.
- 间歇性多重药物静脉注射疗法 (IMIT) 适用于12个月以上耐抗生素耐药的MAB-PD患者.
研究的目的:
- 评估间歇性多药IV治疗 (IMIT) 对耐药性MAB-PD患者的影响.
主要方法:
- 36名耐药性MAB-PD患者通过重复住院接受IMIT,包括阿米卡辛,伊米佩内姆和tigecycline.
- 患者因复发症状或放射性恶化而接受IMIT治疗,同时服用口服/吸入抗生素.
主要成果:
- 所有患者的症状都有所改善.
- 在42%的M-PD患者和70%的M massiliense-PD患者中观察到放射性改善.
- 培养转换率为M-PD的12%和M massiliense-PD的60%.
结论:
- 与间歇性住院治疗的IMIT是一种有益的缓解治疗,用于耐火性MAB-PD.
- 该疗法缓解症状,减缓放射性进展,并减少细菌负担在选定的患者.
- 对IMIT的反应在M-massiliense-PD中比M-abscessus-PD更为明显.
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