认知能力下降是否会影响手语?
Alice Naomi Preti1, Lorenzo Diana2, Rita Castaldo3
1School of Medicine and Surgery, PhD Program in Neuroscience, University of Milano-Bicocca, Monza, Italy. a.preti5@campus.unimib.it.
Aging clinical and experimental research
|September 3, 2023
概括
与健康个体相比,手写签名在阿尔茨海默病 (AD) 和前性痴呆症 (FTD) 患者中几乎没有变化. 这表明签名是这些神经退行性疾病认知衰退的不可靠指标.
科学领域:
- 神经学 神经学
- 认知科学 认知科学
- 法医科学 法医科学 法医科学
背景情况:
- 神经退行性疾病如阿尔茨海默氏症 (AD) 和前性痴呆症 (FTD) 可以影响运动技能和认知功能.
- 手写的签名需要精细运动控制和认知处理,这使得它们对神经系统变化有潜在的敏感性.
研究的目的:
- 研究AD和FTD患者手写签名的变化.
- 要确定使用基于评分者的方法进行的签名分析是否可以作为神经退行症的指标.
主要方法:
- 四位独立评价者评估了103名AD/FTD患者和31名健康对照 (HC) 的签名对.
- 签名收集的平均距离是5年,每个患者组都有一次预诊断.
- 评级人员使用0-1级来判断相似性/差异性,并确定特定特征的变化 (例如空间布局,字母形状).
主要成果:
- 在36%的AD患者和44%的FTD患者中报告了标志性变化,而在HC患者中则为17%.
- 在患者组和HC之间发现了报告变化的显著差异 (p < .01).
- 对于痴呆症患者来说,没有识别出独特的特征变化标志物,变化与临床/人口因素无关.
结论:
- 手写的签名在神经退行性疾病和正常衰老中表现出对变化的抵抗力.
- 对签名变化的主观评估是AD和FTD认知状态的不可靠指标.
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