相关实验视频

Updated: Jul 17, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

Radix Scrophulariae提取物通过MST1/Hippo信号通路对甲状腺功能障碍产生作用

Ning Zhang¹, Tao Ye², Xu Lu³

¹Department of Pharmacy, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, 50001, China.

Chinese journal of integrative medicine

|September 3, 2023

概括

雷迪克斯斯克罗拉里亚 (RS) 提取物通过哺乳动物无菌20样激酶1 (MST1) /河马通路调节甲状腺细胞增殖,亡和自来治疗甲状腺功能过高症. 这项研究证明了RSRS.

科学领域:

药理学和中国传统医学
细胞生物学细胞生物学
内分泌学在内分泌学.

背景情况:

甲状腺功能障碍是一种通过过度的甲状腺激素产生而表现出来的疾病.
哺乳动物无菌20样激酶1 (MST1) /河马途径在细胞增殖,细胞亡和自中发挥作用.
草 (Radix Scrophulariae,简称RS) 是一种中国传统医药,具有潜在的治疗应用.

研究的目的:

为了研究Radix Scrophulariae (RS) 提取物在甲状腺功能障碍症中的治疗机制.
探索通过MST1/Hippo途径通过RS提取物调节甲状腺细胞增殖,细胞亡和自.

主要方法:

在使用levothyroxine sodium的老鼠中诱导甲状腺功能过高.
鼠被用RS提取物或RS提取物和MST1/Hippo途径抑制剂 (XMU-MP-1) 的组合治疗.
甲状腺组织分析了他的病理学变化,戈尔吉囊泡结构,TSH-R表达,亡以及参与增殖,亡和自的关键蛋白质的表达.

主要成果:

RS提取物显著降低了甲状腺体积,并改善了甲状腺功能高大鼠的病理变化.
RS提取物抑制了甲状腺素受体 (TSH-R) 和甲状腺素 (T4) 水平,同时促进了亡和自.
RS提取物上调的MST1/Hippo通路组件 (MST1,p-LATS1,p-YAP) 和亡/自标志物 (Caspase-3,LC3-II/I,ATG5),以及下调的增殖标志物 (PCNA,Cyclin D1).

结论:

拉迪克斯·斯克罗拉里亚 (Radix Scrophulariae) 提取物显示出对甲状腺功能障碍的治疗潜力.
RS提取物通过抑制甲状腺细胞增殖和促进亡和自作用来发挥其作用.
MST1/Hippo通路是RS提取物在治疗甲状腺功能障碍时起作用的关键调解者.

关键词:

在MST1/Hippo信号通路中.拉迪克斯Scrophulariae 提取物提取物灭症 (apoptosis) 是一种死亡的过程.自自是自的过程.甲状腺功能过强症甲状腺功能过强症莱沃西素片莱沃西素片它们的扩散和扩散.

更多相关视频

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

相关概念视频

Synthesis and Regulation of Thyroid Hormones

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...

Functions of Thyroid Hormones

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...

PI3K/mTOR/AKT Signaling Pathway

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...