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在慢性病中,动脉硬,左心室透静功能和功能之间的关系
Balázs Sági1, István Késői2, Tibor Vas1
12nd Dept. of Internal Medicine and Nephrology, Diabetes Centre, Medical School, Clinical Center, University of Pécs, Pacsirta Street 1, Pécs, 7624, Hungary.
BMC nephrology
|September 3, 2023
概括
在IgA脏病 (IgAN) 中,随着功能下降,腹功能障碍和动脉硬性恶化. 在慢性病 (CKD) 中,可以及早检测血管变化.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
- 血管生物学 血管生物学
背景情况:
- 慢性病 (CKD) 和IgA病 (IgAN) 与不良的心血管结果有关.
- 左心室扩张功能障碍和动脉硬是CKD的已知的预后指标.
- 在IgAN中,扩张性功能障碍,动脉硬和功能之间的相互作用需要进一步阐明.
研究的目的:
- 在IgA脏病患者中调查透气功能障碍,动脉硬和功能之间的关系.
- 在慢性病中识别早期血管变化.
主要方法:
- 评估了79名IgA脏病患者和50名对照组.
- 用组织多普勒成像 (Ea, Aa) 测量透气功能.
- 使用硬度指数 (SI) 和大动脉脉冲波速率 (PWVao) 评估动脉硬度.
主要成果:
- 在IGAN患者中,透析功能指数 (Ea/Aa) 和动脉硬度指标 (SI,PWVao) 之间观察到显著的相关性.
- 与早期阶段 (CKD 1-2) 相比,晚期CKD (CKD 3-5) 的Igan患者的透析功能障碍更为普遍.
- 左心室刚度 (LVR) 与动脉硬度 (SI) 和估计的膜过率 (eGFR) 相相关,独立预测因素包括SI的年龄,E/A和E/Ea.
结论:
- 心脏和血管硬度增加与慢性病中的功能下降有关,直接与腹功能障碍有关.
- 早期CKD的血管变化可以通过将CKD患者与对照进行比较来确定.
- 动脉硬和腹功能障碍是IgAN中功能下降的重要指标.
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