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标签强制性的过敏原的挑战验证值:对于最敏感的患者来说,多少太多?
Charlotte G Mortz1, Esben Eller1, Olav Sivertsen Garvik2
1Department of Dermatology and Allergy Centre, Odense Research Centre for Anaphylaxis (ORCA), Odense University Hospital, University of Southern Denmark, Odense C, Denmark.
Allergy
|September 4, 2023
概括
大多数食物过敏个体可以耐受微量过敏原. 蛋是最强大的过敏原,在非常低的剂量中引起敏感患者的反应,影响食品过敏原标签.
科学领域:
- 食物过敏研究 食物过敏研究
- 临床免疫学 临床免疫学
- 确定过敏原值的方法
背景情况:
- 欧盟 (EU) 要求对14种主要的食物过敏原进行标签.
- 准确的过敏原标签依赖于基于人口的食物挑战门.
- 这项研究旨在确定强制标签过敏原的值分布.
研究的目的:
- 评估临床验证的食物过敏患者的值分布.
- 识别特定的过敏原及其剂量-反应关系.
- 为欧盟准确的过敏原标签政策提供信息.
主要方法:
- 从2000年到2022年对口服食品的积极挑战和双盲安慰剂控制的食品挑战 (DBPCFC) 的分析.
- 计算最低观察到的不良影响水平 (LOAEL) 和估计没有观察到的不良影响水平 (NOAEL).
- 使用间隔审查的日志正常分布对数据进行建模.
主要成果:
- 在1229名患者中,1.5%的挑战 (38/2612) 对<5毫克蛋白质.
- 对0.5毫克蛋白质的反应发生在蛋,鱼,花生,牛奶和树果的低种群频率中.
- 蛋是最强烈的过敏原,其中0.24%的蛋过敏患者对<0.5毫克蛋白质反应.
结论:
- 大多数食物过敏患者可以在没有严重反应的情况下容忍微量过敏性食物.
- 蛋是最有可能引起高度敏感个体反应的过敏原,在非常低的剂量下.
- 这些发现支持需要精确的过敏原值数据,以便有效的食品标签.
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