切除术对状细胞贫血患者循环中的微粒的影响
Mohamed-Rachid Boulassel1,2, Khoula Al-Rubkhi1, Jamal Al-Qasabi2
1Department of Allied Health Sciences, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman.
International journal of laboratory hematology
|September 4, 2023
概括
切除术显著增加了状细胞贫血 (SCA) 患者的循环微粒 (MP). 这些红细胞 (RBC) 和血小板 (PLT) MPs的升高水平在手术后持续存在,无论其他SCA因素如何.
科学领域:
- 血液学 血液学 血液学
- 血管生物学 血管生物学
- 生物标志物发现发现
背景情况:
- 循环微粒 (MPs) 是疾病活动的新兴生物标志物,例如状细胞贫血 (SCA).
- 状况对SCA患者的MP水平的影响在很大程度上仍未被描述.
研究的目的:
- 研究SCA患者的状况和循环MP水平之间的关系.
- 描述MPs的细胞起源及其与SCA中的临床和人口因素的关联.
主要方法:
- 对144名稳定状态的SCA患者进行前性研究.
- 流细胞计用于量化MPs的绝对血度.
- 评估MP细胞起源,以及与脏状态 (临床/成像),人口统计,临床状态和治疗的关系.
主要成果:
- 与健康个体相比,SCA患者的RBC衍生的MP和PLT衍生的MP增加了10倍.
- 骨切除SCA患者的MPRBC和MPPLT水平显着更高,而且仍然很高.
- MP水平与去除,年龄,性别,临床严重程度,基尿素治疗,HbF或G6PD缺乏症没有显著关联.
结论:
- 脊髓切除术显然会影响SCA患者的循环MP水平.
- 脊髓切除术后MP水平升高独立于已知的SCA修饰剂和相关物质.
更多相关视频
02:09Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions
Published on: December 20, 2024
315
05:23Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
19.5K
相关概念视频
Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
Bone Marrow Sampling and Transplants
359
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
359
