高龄影响上道尿路癌的激进脏切除术后的生存率
Matteo Ferro1, Sever Chiujdea2, Mihai Dorin Vartolomei2
1Department of Urology, European Institute of Oncology, IRCCS, Milan, Italy; Department of Oncology and Hematology Oncology, Faculty of Medicine and Surgery, University of Milan, Milan, Italy.
Clinical genitourinary cancer
|September 4, 2023
概括
高龄患者 (70岁以上) 患上道泌尿瘤 (UTUC) 经过彻底瘤切除术的患者的整体和癌症特异性存活率明显降低. 年龄是UCU管理的关键预后因素,突出了对老年人群量身定制护理的需要.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 老年医学 老年医学
背景情况:
- 上道泌尿道癌 (UTUC) 是一种罕见的恶性瘤,预后通常不佳.
- 确定预后因素对于优化患者管理和治疗策略至关重要.
研究的目的:
- 调查年龄 (截止70岁) 对UTUC患者复发和生存结果的影响.
- 为了确定高风险的UTUC人口中复发和生存的预测因素.
主要方法:
- 对776名非转移性UTUC患者的回顾性分析,这些患者接受了激进性瘤切除术.
- 使用卡普兰-梅尔和考克斯回归模型,比较年龄在70岁以下和70岁以上的患者之间的结果.
- 评估各种临床和组织病理学因素作为独立的预后.
主要成果:
- 年龄组 (<70岁与>70岁) 之间,静脉内或静脉外复发率没有显著差异.
- 在70岁及以上的患者中,整体存活率和癌症特异性存活率显著下降 (P=.0001).
- 年龄被确定为生存结果的独立预测因素,即使经过对混因素的调整.
结论:
- 与年轻患者相比,70岁及以上的为UTUC进行激进瘤切除术的患者的生存结果较差.
- 年龄是UTUC的重要预后因素,需要专门的老年人护理和管理策略.
- 这些发现强调了考虑年龄在治疗决策和UTUC患者的随访协议中的重要性.
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