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多模式功能磁共振成像在区分p53abn和p53wt子宫内膜癌的价值

Tian Shifeng¹, Wang Yue¹, Zhu Wen²

¹Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China.

Acta radiologica (Stockholm, Sweden : 1987)

|September 4, 2023

概括

多种模式的MRI可以区分p53异常与p53野生型子宫内膜癌 (EC). 像APTw,mDIXON-Quant和DWI这样的先进成像技术为EC分子类型提供了定量评估.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
分子病理学分子病理学

背景情况:

子宫内膜癌 (EC) 是女性常见的一种癌症.
P53基因表达是接受新辅助治疗的EC患者的预后标志物.

研究的目的:

评估多式磁共振成像 (MRI) 在区分p53异常 (p53abn) 和p53野生型 (p53wt) 的实用性.
探索用于EC分子亚型化的定量成像生物标志物.

主要方法:

对47名EC患者 (14p53abn, 33p53wt) 的回顾性分析.
手术前的MRI包括胺质子转移加权 (APTw),T2映射,mDIXON-Quant和扩散加权成像 (DWI).
在p53abn和p53wt组之间测量和比较了定量参数 (APT,T2,R2*,FF,ADC).

主要成果:

与p53wt EC相比,p53abn EC显示出明显更高的APT和R2*值,以及较低的ADC值 (P <0.05).
两组之间T2和脂肪分数 (FF) 值没有发现显著差异 (P > 0.05).
组合APT + R2* + ADC模型实现了0.820的AUC,用于区分p53abn和p53wt EC.

结论:

通过APTw,mDIXON-Quant和DWI技术,可以对p53abn和p53wt EC进行定量分化.
多模态MRI为EC分子亚型的术前定量评估提供了一种新的方法.
这种成像方法对个性化EC管理具有潜在的临床价值.

关键词:

宫内膜癌 (Endometrial carcinoma) 是一种子宫内膜癌.胺基质子转移加权的氨基酸.扩散权重成像技术的使用.磁共振成像技术的使用

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