一些患有纤维肌痛的患者可能患有低酸性肌痛吗? 一个回顾性单中心研究
Patil Injean1, John Tan2, Sandy Lee3
1Cedars Sinai Medical Center, Los Angeles, California.
ACR open rheumatology
|September 4, 2023
概括
在有低性酸酶 (ALP) 的纤维肌痛患者中,可能会怀疑低性酸酶 (HPP). 建议在纤维肌痛患者中对HPP进行查,以预防骨折等并发症.
科学领域:
- 内分泌学 在内分泌学.
- 遗传学 是一个遗传学.
- 类风湿病学 类风湿病学
背景情况:
- 低酸性 (HPP) 是一种罕见的遗传疾病,由于性酸酶 (ALP) 基因突变影响骨矿化.
- HPP可以呈现出各种症状,包括像纤维肌痛 (FM) 这样的慢性疼痛综合征.
- 抗吸收药物可能会在HPP患者中加速非典型的股骨骨折.
研究的目的:
- 调查在被诊断为纤维肌痛的患者中潜在的HPP病例的流行率.
- 评估是否应该在纤维肌痛的差异诊断中考虑HPP.
主要方法:
- 在一个学术中心对成年纤维肌痛患者的回顾性图表审查.
- 分析包括ALP水平,骨折史和其他与骨相关的诊断.
- 审查还涵盖了基因检测,维生素B6,和水平.
主要成果:
- 在611名纤维肌痛患者中,200人患有低ALP水平,57人患有持续低ALP.
- 在持久低ALP患者中,44%的人有骨折史.
- 没有患者接受了HPP的基因检测,也没有检查维生素B6,或的水平.
结论:
- 在9.3%的纤维肌痛患者中观察到持续低的ALP水平,这表明潜在的未诊断的HPP.
- 缺乏具体的测试表明,在这些案例中没有怀疑HPP.
- 在纤维肌痛患者中对HPP进行查是必要的,以便及时诊断和酶替代疗法,防止像骨折这样的严重并发症.
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