矮身是心脏移植发病率和死亡率的一个危险因素
Noah Weingarten1, Amit Iyengar1, Mrinal Patel1
1Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.
Asian cardiovascular & thoracic annals
|September 4, 2023
概括
身高矮增加了心脏移植死亡风险. 这一发现表明,为了获得更好的结果,在患者预后模型中包括身高.
科学领域:
- 心脏病学 心脏病学
- 移植手术 移植手术
- 医学统计 医学统计
背景情况:
- 矮身与心脏手术后死亡率较高有关.
- 身高可能会影响器官移植中的尺寸不匹配.
- 矮身对心脏移植结果的影响尚不清楚.
研究的目的:
- 调查矮身与心脏移植结果之间的关联.
- 为了确定身高矮是否是心脏移植接受者的死亡风险因素.
主要方法:
- 对2000-2022年间成年人心脏移植数据的分析 (n=43,420).
- 接受者根据性别调整的身材分为五个群体.
- 使用卡普兰-梅尔和考克斯回归分析评估死亡率.
主要成果:
- 12.2%的人身高矮,1.8%的人身高非常矮.
- 非常矮的身材与更高的等候名单状态,先天性心脏病和超大体型的捐赠者有关.
- 非常矮的身材与1年,5年和10年生存率的降低以及10年死亡率的增加有关 (HR 1.40).
结论:
- 矮身是心脏移植患者死亡率增加的重要风险因素.
- 心脏移植候选人的预后模型中应考虑身高.
- 进一步的研究可能会探索将矮身与不良移植结果联系在一起的机制.
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