肠道微生物群和艾滋病毒感染妇女的认知功能
Simin Hua1,2, Brandilyn A Peters2, Susie Lee3
1Department of Population Health, Division of Epidemiology, New York University Grossman School of Medicine, New York, NY, USA.
Journal of Alzheimer's disease : JAD
|September 4, 2023
概括
改变的肠道细菌与女性的认知障碍有关,特别是那些感染艾滋病毒的女性. 特定的细菌变化和功能途径为认知功能障碍和阿尔茨海默病风险提供了洞察力.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
背景情况:
- 改变的肠道微生物群与认知功能障碍和阿尔茨海默病有关.
- 有限的研究存在于肠道微生物群和艾滋病毒感染者 (PLWH) 的认知.
研究的目的:
- 调查肠道微生物群组成与艾滋病毒感染和没有艾滋病毒感染的女性认知障碍之间的关联.
- 确定与认知障碍相关的特定细菌种群和微生物功能途径.
主要方法:
- 对446名女性 (302名艾滋病毒感染者) 的横截面研究.
- 神经心理学测试和便样本分析 (16SV4rRNA基因测序).
- PICRUSt用于微生物功能路径预测;ANCOM-II和后勤回归用于分析.
主要成果:
- 较高的特定细菌 (例如,Metanobrevibacter,Eubacterium) 和较低的Veillonella丰度与认知障碍有关.
- 这些关联在HIV+女性中更强,主要与学习和记忆缺陷有关.
- 与认知障碍相关的12个丰富和3个枯竭的微生物功能途径被确定.
结论:
- 肠道微生物群的变化与女性的认知障碍有关,不论艾滋病毒状况如何.
- 研究结果支持肠道微生物群在认知功能障碍和阿尔茨海默病中的作用.
- 特定的细菌种群和通路可能代表认知健康的治疗点.
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