马查多-约瑟夫病的前庭症状学
Zohar Elyoseph1,2,3, Dario Geisinger4, Roy Zaltzman5
1School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.
Journal of vestibular research : equilibrium & orientation
|September 4, 2023
概括
马查多·约瑟夫病 (MJD) 患者表现出显著的双边前庭功能障碍和与双边前庭病变 (BVP) 相一致的症状. 这表明,在未来的诊断标准中,MJD应该被归类为中央前庭病变.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 遗传学 遗传学 是一个
背景情况:
- 马查多·约瑟夫病 (MJD) 是一种自体主导的神经退行性疾病.
- 之前的研究发现,MJD患者的双边水平前庭眼反射 (VOR) 缺陷显著.
- 在MJD中出现前庭症状的存在以前没有详细说明.
研究的目的:
- 为了确定MJD患者是否出现典型的前庭症状,符合双边前庭病变 (BVP) 诊断标准.
- 为了评估MJD除了大脑动之外的前庭症状.
主要方法:
- 21名MJD患者,12名单侧静脉病 (UVP) 患者,15名BVP患者和22名健康对照参与了这项研究.
- 视频头脉冲测试 (vHIT) 用于评估VOR增益.
- 参与者完成了头障碍清单 (DHI),活动特定平衡信心量表 (ABC),视觉量表 (VVS) 和贝克焦虑清单 (BAI).
主要成果:
- 71%的MJD患者表现出显著的双边前庭功能障碍 (水平增益<0.6).
- 与对照组相比,MJD患者在DHI,ABC,VVS和BAI上报告了显著更高的症状水平.
- MJD症状形状与UVP和BVP组的症状形状相似.
结论:
- MJD的特点是显著的VOR损伤和临床症状表明BVP.
- MJD应该被潜在地归类为中央前庭病变,在国际前庭病变分类 (ICVD) 中以BVP为标题.
- 这些发现影响了MJD的临床诊断和潜在的前体康复策略.
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