在消化系统疾病中的乳杆菌reuteri:专注于临床试验和机制
Yijing Peng1,2, Yizhe Ma1,3, Zichen Luo1
1Department of Neonatology, Women's Hospital of Jiangnan University, Wuxi Maternity and Child Health Care Hospital, Wuxi, China.
Frontiers in cellular and infection microbiology
|September 4, 2023
概括
乳杆菌reuteri (L. reuteri) 显示出作为一种经济的益生菌治疗消化系统疾病的希望. 虽然对婴儿结肠和某些感染有效,但对其他疾病需要进一步研究.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 消化系统疾病是一个重大的全球健康挑战,治疗选择有限.
- 乳杆菌reuteri (L. reuteri) 正在成为一种具有成本效益的益生菌,对胃肠道健康有潜在的益处.
研究的目的:
- 审查目前关于各种L. reuteri菌株在治疗常见消化系统疾病中的应用的研究.
- 突出L. reuteri的菌株特异性机制和治疗潜力.
主要方法:
- 使用PubMed,科学网和谷歌学者进行了全面的文献搜索.
- 该综述综合了研究L. reuteri在各种胃肠道疾病中的疗效的研究结果.
主要成果:
- L. reuteri 证明了作为婴儿结肠的预防和治疗剂以及作为腹,便秘和Helicobacter pylori感染的辅助疗法的有效性.
- 临床前研究表明,对功能性腹痛,炎症性肠病,分泌炎,结肠直肠癌和肝脏疾病有潜在的益处,尽管需要进一步的临床研究.
- 治疗效应归因于诸如代谢物生产,微生物组调节,肠道屏障保护和免疫系统调节等机制,这些机制依赖于菌株.
结论:
- L. reuteri通过各种信号通路在维持肠道平衡中发挥着至关重要的作用.
- 这种益生菌代表了对一系列消化系统疾病的有希望的潜在治疗方法,菌株特异性是关键因素.
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