杆菌感染改变了慢性胃炎患者的胃微生物群
Zhaolai Hua1,2, Le Xu3, Jiahui Zhu3
1Guangxi Key Laboratory of Rare and Endangered Animal Ecology, Guangxi Normal University, Guilin, China.
Frontiers in cellular and infection microbiology
|September 4, 2023
概括
病毒性Helicobacter pylori (Hp) 感染显著改变胃微生物群的组成,并减少慢性胃炎患者的多样性. 这表明了针对胃微生物群的潜在治疗策略,用于HP感染治疗.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 基因组学就是基因组学.
背景情况:
- 慢性胃炎通常与Helicobacter pylori (Hp) 感染有关.
- 慢性胃炎患者的胃粘膜微生物群的组成及其与HP感染类型的关系仍然不完全理解.
研究的目的:
- 研究Helicobacter pylori (Hp) 感染对被诊断患有慢性胃炎的患者胃粘膜微生物群的影响.
- 区分病毒性Hp-I和病毒性Hp-II感染对胃微生物群组成和多样性的影响.
主要方法:
- 招募了193名患有慢性胃炎和阳性快速尿素酶试验的患者.
- 将患者分为慢性缩性胃炎 (CAG) 和慢性非缩性胃炎 (nCAG) 组.
- 利用免疫血栓检测hp抗体和16SrRNA基因测序用于胃微生物群的概况.
主要成果:
- 在CAG患者中,Hp-I感染的发生率高于nCAG患者 (71.0%),高于CAG患者 (91.1%)
- 与nCAG患者相比,CAG患者的胃微生物丰富度明显较低.
- 病毒性Hp-I感染降低了CAG患者的微生物多样性 (香农指数),并改变了CAG和nCAG组中的细菌丰度.
结论:
- 病毒性HP感染显著改变胃微生物群,减少微生物多样性,并增强慢性胃炎中的细菌共生关系.
- 这些发现为HP感染期间宿主微生物群相互作用提供了新的见解.
- 表明了针对HP感染的基于微生物群的治疗干预措施的潜力.
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