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在COVID-19疫苗接种后的SARS-CoV-2抗体反应,一个纵向研究

Smita Santosh Chavhan^1,2, Prasad Tukaram Dhikale¹, Balkrishna B Adsul²

¹Department of Community Medicine, HBTMC and Dr. RN Cooper Hospital Mumbai, Maharashtra, India.

Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine

|September 4, 2023

概括

接种COVID-19疫苗后的抗体水平显著下降,第二剂接种后13-17周. 这支持Covishield剂量之间的更长的间隔,并可能解释突破性感染.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
公共卫生公共卫生

背景情况:

了解对COVID-19疫苗的抗体反应对于公共卫生战略至关重要.
长度研究跟踪疫苗接种后免疫系统的变化.

研究的目的:

在医疗保健工作者中调查COVID-19疫苗接种后的抗体反应及其耐用性.
评估疫苗接种计划对抗体标位的影响.

主要方法:

进行了一项涉及两组医疗保健工作者 (HCW) 的纵向研究.
第一组接种了一剂COVID-19疫苗;第二组接种了两剂.
对SARS-CoV-2尖端蛋白进行了定量抗体测试,随访时间为3个月.

主要成果:

抗体标位在第一剂接种后125天显著下降,在第二剂接种后114天显著下降.
在疫苗剂量之间观察到34天的中位数间隔.
报告的副作用和没有副作用的HCW之间没有发现抗体标位的显著差异.

结论:

在第二次Covishield剂量后大约13-17周,抗体标位下降.
这些发现支持印度决定延长Covishield疫苗剂量之间的间隔.
抗体水平下降可能有助于突破COVID-19感染.

关键词:

在 COVID-19 疫情中,豁免权是一种豁免权.展望性研究是指前性研究.这就是SARS-CoV-2病毒.疫苗,疫苗的使用情况.

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