通过细菌对虫的水平基因转移获得的应激弹性
Taruna Pandey1, Chinmay Kalluraya2, Bingying Wang1
1Cardiovascular Research Institute and Department of Physiology, University of California San Francisco, San Francisco, USA.
bioRxiv : the preprint server for biology
|September 4, 2023
概括
横向基因转移允许线虫获得细菌基因以提高弹性. 从细菌中获得的线虫基因rml-3改善了C. elegans的外骨完整性和毒素耐药性.
科学领域:
- 进化生物学是进化的生物学.
- 遗传学 是一个遗传学.
- 生物化学 生化学
背景情况:
- 自然选择驱动着生物体弹性的演变.
- 从细菌获得的水平基因转移 (HGT),特别是域间 HGT (iHGT),是转生动物获得新特征的关键机制.
- 线虫基因rml-3,通过iHGT获得,在外骨弹性中起作用.
结论:
- 一种古老的细菌rml-3同类体的iHGT使线虫中的L-rhamnose生物合成成为可能.
- 这有助于皮肤的完整性和生物体对环境压力的弹性.
- 通过iHGT对细菌基因的化对metazoan进化有显著的贡献.
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