红菜汁介导的肠道微生物群调节改善了肠道上皮质平衡,并改善了结肠炎
bioRxiv : the preprint server for biology
|September 4, 2023
概括
红菜汁通过增强有益的肠道细菌来缓解炎症性肠病 (IBD). 这促进了抗炎反应,改善了肠道屏障功能,改善了结肠健康.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性肠道疾病 (IBD) 的发病与肠道微生物群失调密切相关.
- 准肠道微生物群是IBD的一个有希望的治疗策略.
- 红菜汁 (RCJ) 在改善IBD模型方面显示出潜力,但机制尚不清楚.
研究的目的:
- 研究RCJ调节肠道微生物群的机制,以缓解硫酸 (DSS) 诱导的大肠炎.
- 阐明RCJ对肠道屏障功能和大肠炎炎炎症途径的影响.
主要方法:
- 在小鼠中使用硫酸德克斯 (DSS) 诱导的大肠炎模型.
- 用红菜汁 (RCJ) 进行治疗.
- 评估临床症状,肠道屏障完整性,肠道微生物群组成 (shotgun metagenomics) 和炎症标志物.
主要成果:
- 在DSS诱导的大肠炎中,RCJ治疗改善了体重,减少了便血液和腹.
- 通过减少亡,增加粘素和促进紧密结合蛋白,RCJ增强了肠道屏障功能.
- RCJ调节了肠道微生物群,丰富了短链脂肪酸 (SCFA) 生产细菌,增加了PPAR-γ激活,抑制了NF-κB信号,导致炎症减少和IL-10和T-reg细胞增加.
结论:
- 通过调节肠道微生物群的组成和功能,RCJ改善了DSS诱导的结肠炎.
- RCJ促进有益的SCFA生产,增强肠道屏障的完整性,并具有抗炎作用.
- 这项研究提供了RCJ作为IBD通过肠道微生物群调节的潜在治疗剂的证据.
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