怀孕期间吸烟及其对胎盘体重的影响:孟德尔的随机化研究
Annika Jaitner1, Marc Vaudel2,3,4, Krasimira Tsaneva-Atanasova5,6
1Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.
medRxiv : the preprint server for health sciences
|September 4, 2023
概括
孕妇在怀孕期间吸烟会导致胎盘体重增加,而不是胎盘与胎盘相比降低出生体重. 在怀孕早期戒烟与更健康的胎盘发育有关.
科学领域:
- 产科和妇科 产科和妇科
- 生殖健康 生殖健康
- 围产儿医学 围产儿医学
背景情况:
- 怀孕期间母亲吸烟与后代出生体重降低有关,可能是由于胎盘功能受损.
- 观察性研究显示,吸烟与胎盘体重的关联有相互矛盾的结果.
- 这项研究研究了怀孕早期戒烟对胎盘体重的因果关系.
研究的目的:
- 估计母亲戒烟对胎盘体重的因果关系.
- 为了确定吸烟强度对胎盘体重的影响.
主要方法:
- 一个样本的孟德尔随机化被采用来自阿文长度研究的父母和孩子 (ALSPAC) 和挪威母亲,父亲和孩子队列研究 (MoBa) 的数据.
- 分析的重点是使用遗传仪器SNP rs1051730 (CHRNA5-CHRNA3-CHRNB4) 戒烟的怀孕前吸烟者.
- 使用元分析和回归模型来评估胎盘体重和胎盘体重相对于胎盘体重的后代出生体重.
主要成果:
- 与戒烟相比,在怀孕早期继续吸烟与175克更高的胎盘体重有关.
- 在妊娠的第一季度,每天抽一支香烟,胎盘体重增加12克.
- 怀孕结束时戒烟也产生了类似的结果,在继续吸烟的吸烟者中,相对于胎盘体重,出生后体重较低的证据很弱.
结论:
- 在怀孕期间继续吸烟的母亲因果性地增加了胎盘体重.
- 在怀孕早期戒烟可能会导致更健康的胎盘发育.
- 这些发现有助于理解母亲吸烟,胎盘功能和后代结果之间的复杂关系.
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