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Updated: Jul 17, 2025

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
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Published on: June 24, 2021

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在本地序列上下文中对近端和远端拼接调节元件进行深入选

Yocelyn Recinos1, Dmytro Ustianenko1,2, Yow-Tyng Yeh1

  • 1Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA.

bioRxiv : the preprint server for biology
|September 4, 2023
PubMed
概括

研究人员开发了基于CRISPR的选工具SpliceRUSH,用于在基因中映射拼接调节元件 (SREs). 这种方法在SMN2基因中确定了新型SREs,推动了针对脊髓肌肉缩等疾病的基于RNA的药物发现.

关键词:
在SMN2中使用SMN2.另一个替代拼接方法是拼接.无意义的寡核酸 (ASO)dCas13d/指导RNA的使用高通量屏幕的高通量屏幕拼接 - 监管要素 (SREs) 的相关内容

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