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相关概念视频

Regulated Protein Degradation02:58

Regulated Protein Degradation

7.4K
It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
7.4K
The Proteasome01:13

The Proteasome

886
Eukaryotic cells can degrade proteins through several pathways. One of the most important among these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. This involves participation of a series of enzymes including— E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
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相关实验视频

Updated: Jul 17, 2025

Single-Cell Quantification of Protein Degradation Rates by Time-Lapse Fluorescence Microscopy in Adherent Cell Culture
12:06

Single-Cell Quantification of Protein Degradation Rates by Time-Lapse Fluorescence Microscopy in Adherent Cell Culture

Published on: February 4, 2018

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评估蛋白质体衰变中的单细胞变异性.

Sukanya Das1, Abhyudai Singh2, Premal Shah1

  • 1Department of Genetics, Rutgers University.

bioRxiv : the preprint server for biology
|September 4, 2023
PubMed
概括
此摘要是机器生成的。

基因表达噪声源于蛋白质衰变的可变性. 这项研究揭示了蛋白质降解率的细胞间显著差异,影响了基因表达的随机性.

科学领域:

  • 分子生物学分子生物学
  • 细胞生物学 细胞生物学
  • 生物物理学的生物物理.

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Assaying Proteasomal Degradation in a Cell-free System in Plants
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Assays for the Degradation of Misfolded Proteins in Cells
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Assays for the Degradation of Misfolded Proteins in Cells

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相关实验视频

Last Updated: Jul 17, 2025

Single-Cell Quantification of Protein Degradation Rates by Time-Lapse Fluorescence Microscopy in Adherent Cell Culture
12:06

Single-Cell Quantification of Protein Degradation Rates by Time-Lapse Fluorescence Microscopy in Adherent Cell Culture

Published on: February 4, 2018

8.7K
Assaying Proteasomal Degradation in a Cell-free System in Plants
07:43

Assaying Proteasomal Degradation in a Cell-free System in Plants

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Assays for the Degradation of Misfolded Proteins in Cells
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背景情况:

  • 基因表达表现出蛋白质和mRNA水平的固有变异性 (噪音),即使在相同的细胞中.
  • 这种噪音通常归因于转录和翻译,忽视了蛋白质衰变的动态.
  • 了解蛋白质衰变对于完整的基因表达噪声模型至关重要.

结论:

  • 蛋白质衰变速率在单细胞水平上表现出显著的变化.
  • 蛋白质衰变中的随机性有助于整体的基因表达噪声.
  • 对基因表达噪声的准确建模需要纳入蛋白质衰变的复杂动力学.