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在老年大脑中,扩散张力成像变异的特征模式

Chenyu Gao¹, Qi Yang², Michael E Kim²

¹Vanderbilt University, Department of Electrical and Computer Engineering, Nashville, United States.

medRxiv : the preprint server for health sciences

|September 4, 2023

概括

了解扩散张力成像 (DTI) 变异性对于大型研究至关重要. 我们分析了来自1035名受试者的DTI数据,发现年龄,性别和运动等因素会影响大脑各区域的DTI度量变异.

科学领域:

神经成像是一种神经成像.
生物统计学生物统计学
医学物理医学物理

背景情况:

大规模的神经成像分析需要理解数据变异.
扩散张力成像 (DTI) 噪声在空间上有所变化,需要仔细的统计假设.
生理学,受试者遵守和扫描仪相互作用影响DTI的变化.

研究的目的:

描述生理学,受试者遵守和扫描器相互作用在DTI变异性中的作用.
在同质区域中使用衍生指标的空间方差来建模DTI变异性.
为了研究共变量如何影响不同大脑区域的DTI度量变异.

主要方法:

在巴尔的摩长度老化研究 (BLSA) 中,分析了来自1035名受试者 (22.4-103岁) 的DTI数据.
通过四种细分方法定义的兴趣区域 (ROI) 内的DTI标量变异的评估.
调查差异和共变量之间的关系:年龄,时间间隔,运动,性别和扫描会话.

主要成果:

对DTI变异的共变效应在ROI之间是异质的和双边对称的.
会议间隔,性别和运动显着与特定大脑区域的分数异位变异 (FA) 差异有关.
在DTI扫描期间,头部运动会增加.

结论:

协变量对DTI变量的影响是复杂的,并且取决于区域.
研究人员应报告差异估计,并在DTI分析中考虑异性模型.
这项研究为考虑区域DTI指标差异的规划研究提供了基础.

关键词:

在 DTI 中,DTI 是指DTI.老化的老化衰老的老化大脑大脑大脑的大脑大脑运动运动运动运动运动.差异差异是指差异的差异.

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