职业农场工作活动影响工人的室内家庭微生物群
Kathryn R Dalton1, Mikyeong Lee1, Ziyue Wang2
1Genomics and the Environment in Respiratory and Allergic Health Group, Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.
medRxiv : the preprint server for health sciences
|September 4, 2023
概括
农场工作任务和农药使用显著改变了农民家中的室内尘埃微生物群. 这些职业暴露可以通过修改家庭微生物环境来影响农场工人和他们的家庭的健康.
科学领域:
- 环境微生物学环境微生物学
- 职业健康 职业健康 职业健康 职业健康
- 室内建筑环境 室内建筑环境
背景情况:
- 农场工作涉及各种影响农民健康的暴露.
- 室内微生物组可能会调解农业暴露的健康影响.
- 职业暴露对家庭微生物组成的影响在很大程度上是未知的.
研究的目的:
- 调查农场工作活动和农药使用与农民家中的室内微生物组之间的关联.
- 分析特定农场任务和农药暴露对室内尘埃微生物群落的影响.
主要方法:
- 来自468个男性农民卧室的尘埃样本的全基因组猎枪测序.
- 关于6项农场工作任务和26种农药成分 (现行和禁止) 的问卷数据.
- 微生物多样性和组成的统计分析与暴露相关.
主要成果:
- 所有6个农场工作任务都增加了微生物多样性和改变了微生物组成.
- 对农场任务的总和观察到积极的剂量反应.
- 目前的草甘和过去的林丹使用与多样性增加有关.
- 多种农药与改变的微生物组成和特定微生物丰富度有关.
结论:
- 特定的农场活动和农药暴露显然会影响室内尘埃微生物群.
- 职业农场暴露可能会通过室内环境修改影响工人和家庭的健康.
- 研究结果表明,未来在农业环境中进行健康干预的潜在目标.
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