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人体血细胞被设计为分泌双特异性驱动有效的in vivo杀死白血病

Tyler F Hill^1,2, Parnal Narvekar², Gregory Asher²

¹University of Washington, Medical Scientist Training Program, Seattle WA.

bioRxiv : the preprint server for biology

|September 4, 2023

概括

工程血细胞 (ePC) 可以分泌两种特异性抗体以向并杀死白血病细胞. 这种方法在临床前模型中显示出持久的局部癌症治疗的前景.

科学领域:

免疫学免疫学免疫学
生物技术是生物技术.
在瘤学瘤学.

背景情况:

双特异性抗体对于治疗急性白血病至关重要.
基因组工程使人体血细胞 (ePC) 能够分泌治疗性蛋白质,并在体内长期植入.
翻译ePC用于癌症治疗需要高效的双特异性抗体生产和分泌.

结论:

工程等离子体细胞显示出作为双特异抗体的持久,局部传递系统的潜力.
这一战略支持进一步开发用于急性白血病和其他癌症的ePC.
临床前数据强调了ePC在癌症治疗中的治疗潜力.

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