肝硬化患者的门静脉血栓症:发生了什么错误?
Doina Georgescu1, Oana-Elena Ancusa1, Daniel Azoulay2
1Center of Advanced Researches in Cardiovascular Diseases and Hemostaseology, Department of Internal Medicine I, "V Babes" University of Medicine and Pharmacy, Timisoara, Romania.
International journal of general medicine
|September 4, 2023
概括
患有肝硬化和门静脉血栓症的患者表现出炎症标志物升高和肠道微生物群变化. 这些因素,以及临床特征,与疾病严重程度有关.
科学领域:
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
- 微生物学 微生物学
背景情况:
- 肝硬化 (LC) 是一个重要的健康问题.
- 门静脉血栓塞 (PVT) 是LC患者常见的并发症.
- 在LC中肠道微生物群,炎症和PVT之间的相互作用尚未完全理解.
研究的目的:
- 为了研究LC和PVT患者的炎症生物标志物.
- 分析便中的功能性细菌群及其与PVT的关联.
- 探索肠道失调,炎症和LC中的PVT严重程度之间的联系.
主要方法:
- 一项观察性研究涉及300名参与者:200名LC患者 (有或没有PVT) 和100名健康对照.
- 评估临床特征,炎症生物标志物 (TNF-α,CRP,D-二次体) 和肠道微生物群组成.
- 相关性和回归分析以确定PVT严重程度的预测因素.
主要成果:
- 在PVT组中,患者的年龄,吸烟史,急诊,Child-Pugh评分和代谢障碍均较高.
- 在PVT组中观察到瘤亡因子 (TNF) -α,C-反应蛋白 (CRP),D-二次体 (D-D) 和肠道失生症的显著差异.
- 在PVT严重程度和TNF-alpha,CRP,D-D和脂多糖 (LPS) 阳性细菌之间发现了强烈的相关性. 食道静脉,年龄和腹痛是独立的预测因素.
结论:
- 患有PVT的LC患者表现出高的炎症标志物和改变的肠道微生物群.
- 虽然LPS阳性肠道微生物群与炎症和PVT严重程度相关,但CRP,TNF-alpha和D-D是独立的预测因素.
- 这些发现强调了炎症和肠道失调在PVT发展和LC进展中的作用.
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