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在怀孕期间暴露于神经疾病的药物 - 考虑长期影响的时候了吗?

Chen Liu¹, Samuel Pace², Rebecca Bromley^3,4

¹Preventive Neurology Unit, Wolfson Institute of Population Health, QMUL, UK.

EClinicalMedicine

|September 4, 2023

概括

在怀孕期间治疗成人发病的神经疾病需要平衡孕产妇健康益处与胎儿风险. 从产前药物暴露的长期神经发育结果需要进一步的研究.

科学领域:

神经学神经学
发育神经科学的发展神经科学.
药理学药理学是指药理学的学科.

背景情况:

许多长期的神经疾病,包括,偏头痛和神经炎症疾病,在年轻成人时被诊断出来.
慢性神经系统疾病往往需要终身治疗,以控制症状或改变疾病.
在怀孕期间管理这些疾病需要平衡母亲治疗的益处与药物暴露的潜在胎儿风险.

研究的目的:

审查现有证据,对治疗常见的成人发病的神经疾病对胎儿神经发育的长期影响.
为了突出评估长期数据的重要性,由于对氨酸暴露的担忧.
讨论改善未来关于这个主题知识的策略.

主要方法:

对现有关于在成年早期诊断的长期神经疾病研究的文献综述.
对治疗,偏头痛和神经炎症疾病的证据的审查.
在怀孕期间母亲暴露于药物后,对胎儿结果的数据分析.

主要成果:

关于短期胎儿结果的数据正在增加,但关于长期神经发育影响的信息仍然有限.
胎儿瓦酸盐暴露与严重的长期神经发育结果之间的关联强调了需要更多数据的必要性.
关于治疗,偏头痛和神经炎症疾病的长期影响的证据正在合成.

结论:

对于用于治疗常见成人发病的神经疾病的药物对神经发育长期影响的更全面的数据有着迫切的需要.
未来的研究应该专注于捕捉和评估长期结果,以更好地告知临床实践和患者咨询.
需要改进策略,以提高我们对治疗这些疾病的孕妇的风险和益处的理解.

关键词:

是一种病.豁免权是一种豁免权.长期的结果长期的结果神经发育神经发育神经炎症是一种神经炎症.怀孕怀孕怀孕怀孕

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