与SARS-CoV-2感染相关的遗传变异也会影响肺功能和喘严重程度
Milca de Jesus Silva1, Candace Machado de Andrade1, Bianca Sampaio Dotto Fiuza1
1Instituto de Ciências da Saúde, Universidade Federal da Bahia, Brazil.
与严重的COVID-19结局相关的遗传变异也会增加喘严重程度并降低肺功能. 在ABO,CCR9,FYCO1,LZTFL1和SLC6A20中的特定基因多态性增加了喘风险,而XCR1显示出保护作用.
科学领域:
- 遗传学和基因组学 在
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- 主体遗传因素与COVID-19的严重程度有关.
- 全基因组关联研究确定了特定基因 (SLC6A20,LZTFL1,CCR9,FYCO1,CXCR6,XCR1) 和ABO血型附近的COVID-19易感位置.
- 这些遗传因素与肺功能/严重喘之间的关联需要研究.
研究的目的:
- 为了研究COVID-19易感基因中的多态性和肺功能/严重喘之间的关系.
- 评估特定基因变异在巴西人口中的喘表型中的作用.
主要方法:
- 使用多民族全球阵列小组,从ProAR队列中对784个人进行基因定型.
- 评估SLC6A20,LZTFL1,CCR9,FYCO1,CXCR6,XCR1和ABO血型基因中的多态性.
- 对严重喘,呼吸道阻塞和FEV1可逆性的后勤回归分析,调整为共变量;还进行了链接不平衡,单元型,基因得分和in silico分析.
主要成果:
- ABO基因多态 (rs8176733,rs8176725) 与严重喘,呼吸道阻塞和FEV1逆转性缺乏的风险增加有关.
- 在CCR9,FYCO1,LZTFL1和SLC6A20中的多态性被确定为严重喘和/或呼吸道阻塞的危险因素.
- XCR1多态表现出对严重喘和呼吸道阻塞的保护作用;较多的风险等位基因与更糟糕的喘结果相关.
结论:
- 此前与COVID-19患者呼吸衰竭相关的遗传多态性与喘患者对严重喘的易感性增加和肺功能降低有关.
- 这些发现突出了影响感染性和慢性呼吸道疾病的呼吸道健康结果的共同遗传途径.
更多相关视频
07:15Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
09:34Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
相关概念视频
Single Nucleotide Polymorphisms-SNPs
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Asthma-I: Introduction
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Comparing Copy Number Variations and SNPs
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
