评估内皮功能障碍的循环可溶性标志物和与PE相关的风险因素:加纳北部的一个多中心纵向病例控制研究
Benjamin Ahenkorah1,2, Samuel Asamoah Sakyi1, Linda Ahenkorah Fondjo1
1Department of Molecular Medicine, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Heliyon
|September 4, 2023
概括
孕前 (PE) 与内皮功能障碍有关,观察到N-终端前脑性尿素 (NTpro-BNP) 的升高和神经活素-1的降低. 这些标志物,以及胎盘问题,表明在PE中存在显著的孕产妇和胎儿风险.
科学领域:
- 产科和妇科 产科和妇科
- 心血管研究研究心血管研究
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 内皮功能障碍与妊娠前 (PE) 有关.
- 塞尔E1/PAI-1,NTpro-BNP和神经平素-1是与内皮功能障碍相关的标记物.
- 在PE病理生理学中,关于这些标记物的数据有限.
研究的目的:
- 在怀孕和没有PE的孕妇中调查Serpin E1/PAI-1,NTpro-BNP和神经平素-1的水平.
- 为了将这些标志物与PE中的胎儿-母亲并发症和胎盘病理相关联.
主要方法:
- 一项多中心病例控制研究,涉及127名孕妇 (53名孕妇有PE,74名孕妇为对照).
- 对生物标志物 (NTpro-BNP,neuropilin-1) 的检测,血液学参数和胎盘寄生虫的确定.
- 评估胎盘疟疾,细胞病变病变,母亲的心率和胎儿动脉多普勒指数 (RI,SD).
主要成果:
- 患有PE的女性的血小板数量较低 (p=0.02) 和红细胞分布宽度 (RDW) 增加 (p=0.01).
- 在PE患者中,NTpro-BNP显著升高 (p=0.01) 和neuropilin-1降低 (p=0.03).
- 在PE中观察到母亲心率升高,多普勒指数 (RI,SD) 和胎盘输血不良病变.
结论:
- 孕前与显著的内皮功能障碍有关,由改变的生物标志物水平和胎盘病理学证明.
- 增加的NTpro-BNP,RI和SD,加上减少的神经皮林-1,表明PE中严重的内皮质乱.
- 这些病理变化有助于孕前的不良孕产妇和产周结果.
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