预防与治疗类风湿性关节炎
Lars Klareskog1, Lars Alfredsson2
1Rheumatology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Immunotherapy advances
|September 4, 2023
概括
由于了解疾病发展的进展,预防类风湿性关节炎 (RA) 现在是可行的. 未来的研究和临床实践应优先考虑RA预防策略,包括公共卫生和精确方法.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 预防医学 预防医学
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性,无法治愈的疾病,主要关注治疗而不是预防.
- 目前的RA治疗方法可以治疗关节损伤,但不能治疗或消除持续治疗的需要.
- 有限的研究已经探索了RA的预防策略,尽管它有很大的影响.
研究的目的:
- 审查当前对类风湿性关节炎 (RA) 发展的理解.
- 倡导将RA预防纳入研究议程和临床实践.
- 概述潜在的公共卫生和RA的精确预防策略.
主要方法:
- 审查关于血清阳性RA的纵向进展现有知识.
- 讨论基于公共卫生的预防模式.
- 探索"精确预防"战略,包括风险识别,监测和有针对性的干预措施.
主要成果:
- 有足够的知识来支持RA预防作为主要的研究和临床重点.
- 对于RA,可以制定公共卫生和精确预防策略.
- 精确预防包括识别高风险个体进行监测和干预,如改变生活方式或药物治疗.
结论:
- 目前对RA病变的理解支持向预防转变.
- 广泛的公共卫生措施和有针对性的精确预防策略对RA都是可行的.
- 精确预防的成功取决于开发能够诱导长期耐受疾病诱导免疫力的疗法.
相关概念视频
Rheumatic Heart Disease III: Medical Management
12
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
12
Preventive Healthcare Services
1.0K
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
1.0K
Levels of Health Promotion and Illness Prevention
12.7K
Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
In primary prevention, actions taken before disease onset prevent the disease from...
12.7K
Rheumatic Heart Disease IV: Nursing Management
18
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
18
Rheumatic Heart Disease I: Introduction
16
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
16
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
195
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
195


