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通过Helicobacter pylori感染,在炎症性肠道疾病中调节免疫反应

Gabriella Feilstrecker Balani¹, Mariana Dos Santos Cortez¹, Jayme Euclydes Picasky da Silveira Freitas¹

¹Campus Toledo, Universidade Federal do Paraná, Toledo 85.919-899, Paraná, Brazil.

World journal of gastroenterology

|September 4, 2023

概括

杆菌感染可能通过改变肠道微生物群和免疫反应来影响炎症性肠道疾病 (IBD). 这个细菌这个细菌.

科学领域:

微生物学和免疫学
胃肠病学胃肠病学

背景情况:

许多研究表明,Helicobacter pylori (H. pylori) 感染和炎症性肠道疾病 (IBD) 之间存在关联.
H. pylori 在IBD 发病过程中的确切作用仍在争论中,但它似乎影响了疾病的进展.

研究的目的:

探索H. pylori感染可能影响炎症性肠道疾病的机制.
研究H. pylori对肠道微生物群,免疫反应模式和先天免疫成分的影响.

主要方法:

审查现有研究,调查H. pylori和IBD之间的联系.
对H. pylori对肠道微生物多样性和当地化学环境的影响的分析.
检查H. pylori对宿主免疫反应的调节,包括T辅助细胞和巨细胞两极分化.
研究细菌毒性因素和微环境变化,促进H. pylori的持久性.
评估H. pylori感染与先天性免疫组件 (如NLRP3炎症体) 之间的关系.

主要成果:

杆菌感染似乎改变了肠道微生物群的多样性和当地化学特征.
细菌调节免疫反应,转向一种不太具有侵略性的炎症特征 (Th2 / M2) 并抑制Th1 / M1反应.
细菌毒性因素 (例如,CagA,HP-NAP) 和微环境变化 (例如,胃pH增加) 导致免疫调节和持久性.
杆菌感染与先天性免疫组件,特别是NLRP3炎症体,存在因果关系.
这种与先天性免疫的相互作用似乎使IBD朝着更好的预后发展.

结论:

杆菌感染通过调节肠道微生物群和免疫反应影响IBD.
该细菌促进组织修复和较少的炎症状态的转变,可能通过先天免疫路径改善IBD预后.
了解这些相互作用对于治疗H. pylori感染患者的IBD至关重要.

关键词:

细胞毒素相关的抗原A基蛋白.我们的肠道微生物群.在Helicobacter Pylori的研究中,杆菌的中性粒细胞激活蛋白质.免疫学调节免疫学调节炎症性肠病是一种炎症性肠病.含有3个炎症体的NLR家族皮林域.

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