在日本的2型糖尿病中,患者更喜欢每周服用一次剂量
Rohini Sen1, Alan L Shields1, Koichiro Atsuda2
1Adelphi Values, Boston, MA, USA.
Journal of health economics and outcomes research
|September 4, 2023
概括
患有2型糖尿病 (T2DM) 的患者表现出不同的剂量偏好. 虽然每日剂量通常是首选的,但年轻的,工作的和以前没有接受过治疗的患者更喜欢每周一次 (QW) 的口服药物,以减少负担.
科学领域:
- 内分泌学和新陈代谢学
- 药理学 药理学是指药理学的学科.
- 患者报告的结果
背景情况:
- 坚持2型糖尿病 (T2DM) 疗法经常受到复杂的剂量方案的阻碍.
- 每周一次 (QW) 口服T2DM药物与每日 (QD,BID,TID) 疗程的比较价值仍然不清楚.
- 了解患者对T2DM剂量的偏好对于改善治疗坚持至关重要.
研究的目的:
- 在2型糖尿病 (T2DM) 中,确定患者子组和与偏好每周一次 (QW) 剂量而不是每日剂量相关的特征.
- 分析影响QW和T2DM管理的每日口服药物治疗方案之间的选择因素.
主要方法:
- 在日本的T2DM患者中进行了一项横截面在线调查.
- 患者被分为三组:仅服用口服低血糖药物,与胰岛素联合治疗和以前未接受过治疗.
- 使用后勤回归和分类以及回归树分析来确定剂量偏好的预测因素.
主要成果:
- 总体而言,55.5%的人更喜欢每日 (QD) 剂量,而33.3%的人更喜欢每周一次 (QW) 剂量.
- 对于未经治疗的患者,年轻人 (≤64岁),全职工作者以及服用0-1或>6种药物的患者,对QW剂量的偏好显着更高.
- 选择QW的主要原因包括减少日常负担 (47.8%),减少心理负担 (14.6%),减少忘记 (12.5%).
结论:
- 患者对T2DM剂量方案的偏好各不相同.
- 虽然一般偏爱每日剂量,但显著的部分,特别是年轻,工作和未经治疗的患者,更喜欢每周服用一次口服药物.
- 偏好QW剂量是由感知较低的负担和更好的便利驱动的.
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