在18岁的瑞典双胞胎中,酒精使用障碍的患病率和遗传性
Malin Hildebrand Karlén1, Ann-Sophie Lindqvist Bagge2, Ulf Berggren3
1Centre for Ethics, Law and Mental Health, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden Department of Forensic Psychiatry, National Board of Forensic Medicine, Gothenburg, Sweden Department of Psychology, University of Gothenburg, Gothenburg, Sweden.
Nordisk alkohol- & narkotikatidskrift : NAT
|September 4, 2023
概括
遗传和环境因素影响18岁双胞胎的酒精使用障碍 (AUD). 观察到适度的遗传性 (37-50%),性别之间存在明显的遗传和环境影响.
科学领域:
- 行为遗传学 行为遗传学
- 精神病学是一个精神病学.
- 双胞胎研究 双胞胎研究
背景情况:
- 在双胞胎研究中,酒精使用障碍 (AUD) 的遗传概率估计有显著差异 (30-78%).
- 方法上的差异,如AUD值和样本年龄的变化,可能解释了这种变化.
研究的目的:
- 为了确定AUD在18岁瑞典双胞胎的全国性样本中的遗传性.
- 对AUDs的遗传和环境影响的潜在性别差异进行调查.
主要方法:
- 使用了对8,330名瑞典双胞胎的数据的单变异性性别限制双胞胎分析.
- 雇员的AUDIT分数,特定的AUDIT截止值 (AUDIT-10,AUDIT-C) 和酒精依赖的风险组分类.
主要成果:
- 危险/有害的酒精使用率为57.1% (女性59.0%,男性54.4%),潜在的有害使用率为26.5% (女性31.1%,男性20.0%).
- 对AUD的中度遗传概率估计在0.37到0.50之间.
- 性别限制模型表明,在AUDs的遗传和环境影响方面,有品质性的性别差异.
结论:
- 青春晚期AUD的遗传性是中度的,有来自共同和非共同的环境因素的显著贡献.
- 遗传和/或环境因素中的质性性别差异影响男性和女性之间的AUD变化.
- 研究结果表明,AUD在青少年男性和女性中具有不同的病因路径.
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