患有Mpox感染的患者中的住院风险 - 倾向性得分匹配分析
Andrés F Henao-Martínez1, Chloe M Orkin2,3, Boghuma K Titanji4
1University of Colorado Anschutz Medical Campus, 12700 E. 19th Avenue, Mail Stop B168, Aurora, CO 80045, USA.
Therapeutic advances in infectious disease
|September 4, 2023
概括
(Mpox) 住院的预测因素包括黑人,艾滋病毒感染,严重的直肠炎和乳酸脱酶升高. 识别这些因素对于管理Mpox的严重程度至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 麻疹 (Mpox) 是一种重新出现的病毒性疾病,到2023年5月,全球有超过87,000例病例.
- 与Mpox相关的住院住院的预测因素尚未得到充分确立.
- 了解风险因素对于管理正在进行的疫情至关重要.
研究的目的:
- 为了比较入院和非入院患者与Mpox的临床特征和结果.
- 确定与Mpox住院相关的独立预测因素.
主要方法:
- 进行了一项多中心回顾性病例控制队列研究.
- 倾向性得分匹配被用来分析来自全球卫生网络 (TrinetX) 的数据.
- 1477名Mpox患者的临床特征和结果在不同组之间进行了比较.
主要成果:
- 在1477名患者中,有6%被住院治疗. 在倾向性得分匹配后 (每组80名患者),黑人患者 (51%对33%),艾滋病毒感染者 (50%对20%) 和结尾炎患者 (44%对12.5%) 的住院病例更频繁.
- 蒙波克斯住院的独立预测因素包括感染艾滋病毒的黑人,严重的直肠炎,需要阿片类药物的疼痛以及乳酸脱酶的升高.
结论:
- 已经确定了预测Mpox住院的关键因素.
- 这些发现强调了识别高风险人群和临床表现的重要性,以便及时进行干预.
- 需要进一步的研究和临床警,以减轻Mpox的严重程度并降低住院率.
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