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Updated: Jul 17, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

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与疾病相关的突变A554V破坏了DNMT1的正常自身抑制

Rebecca L Switzer1, Zach J Hartman2, Geoffrey R Hewett3

  • 1Department of Chemistry, Bucknell University, Lewisburg, PA 17837, USA.

DNA
|September 4, 2023
PubMed
概括

基因甲基转移酶1 (DNMT1) 的突变破坏了其调节性RFTS域,导致过度活跃的酶. 这种过度活跃可能会导致神经退行性疾病中DNA甲基化增加.

关键词:
通过DNA甲基化.在DNA甲基转移酶中.表观遗传学是指表观遗传学.神经退行性疾病的神经退行性疾病

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