阿司匹林与LMWH用于骨科手术后静脉瘤预防
Qingqing Wei1, Jing Sun1, Yusuo Bai2
1Department of Critical Care Medicine, Emergency General Hospital, Beijing, 100028, PR China.
Open medicine (Warsaw, Poland)
|September 4, 2023
概括
低分子量肝素 (LMWH) 和阿司匹林在骨科手术后预防静脉血栓栓塞 (VTE) 的安全性相似. 与机械设备相结合的阿司匹林可能会降低深静脉血栓塞 (DVT) 的风险.
科学领域:
- 整形外科手术 整形外科手术
- 药理学 药理学是指药理学的学科.
- 血管医学 血管医学
背景情况:
- 低分子量肝素 (LMWH) 是预防外科手术期间静脉血栓塞栓症 (VTE) 的常见选择.
- 一些学者也认为阿司匹林是用于静脉瘤预防的.
- 证据比较阿司匹林和LMWH用于骨科手术中VTE预防需要合成.
研究的目的:
- 评估阿司匹林与LMWH在接受骨科手术的患者的静脉瘤预防中的安全性和有效性.
- 为了比较包括全因死亡率,深静脉血栓塞 (DVT) 和肺栓塞 (PE) 在内的结果.
主要方法:
- 一项对6项随机对照试验的元分析,涉及13,851名患者.
- 通过电子数据库搜索确定了研究,截至2023年2月24日.
- 分析的结果包括死亡率,DVT,PE,伤口感染和伤口并发症.
主要成果:
- 在阿司匹林和LMWH组之间没有观察到任何原因死亡率,PE,伤口感染或伤口并发症的显著差异.
- 与LMWH相比,单独的阿司匹林显示了较高的DVT风险.
- 在阿司匹林与机械设备结合和LMWH (RR 0.61 [95% CI 0.27-1.39]) 之间,DVT的风险是可比的.
结论:
- 阿司匹林和LMWH在骨科手术后的VTE预防中表现出相似的安全性.
- 阿司匹林单一治疗与较高的DVT风险相关,而不是LMWH.
- 建议将阿司匹林与机械设备相结合,作为这种患者群体中潜在有效的静脉瘤预防策略.
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